Signaling Pathway for RKIP and Let-7 Regulates and Predicts Metastatic Breast Cancer

Thank you for submitting your manuscript for consideration by the EMBO Journal. It has now been seen by two referees whose comments are enclosed. As you will see, both referees express interest in your work and are broadly in favour of publication, pending satisfactory revision. Both referees request a number of additional experiments, as well as various changes and clarifications to the text. I would just draw your attention to two points. Firstly, referee 1 argues that it would be important to measure let7 levels directly in breast tumour samples, and I agree that this would be very valuable; currently the use of predicted targets as a readout of let7 is rather indirect. Secondly, referee 2 questions whether the identified pathway is also relevant upon orthotopic transplantation of breast cancer cells: it would be important to address this issue experimentally.